USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: LEG3_HUMAN USC-OGP 2-DE database:  LEG3_HUMAN LEG3_HUMAN General information about the entry View entry in simple text format Entry name LEG3_HUMAN Primary accession number P17931 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Galectin-3; Short=Gal-3; AltName: Full=35 kDa lectin; AltName: Full=Carbohydrate-binding protein 35; Short=CBP 35; AltName: Full=Galactose-specific lectin 3; AltName: Full=Galactoside-binding protein; Short=GALBP; AltName: Full=IgE-binding protein; AltName: Full=L-31; AltName: Full=Laminin-binding protein; AltName: Full=Lectin L-29; AltName: Full=Mac-2 antigen;. Gene name Name=LGALS3 Synonyms=MAC2 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1272: pI=7.85; Mw=27912 SPOT OGP-1273: pI=5.83; Mw=27756 SPOT OGP-1274: pI=6.07; Mw=27522 Cross-references UniProtKB/Swiss-Prot P17931; LEG3_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name LEG3_HUMAN Primary accession number P17931 Secondary accession number(s) B2RC38 Q16005 Q6IBA7 Q96J47 Sequence was last modified on  November 25, 2008 (version 5) Annotations were last modified on  March 15, 2017 (version 199) Name and origin of the protein Description RecName: Full=Galectin-3; Short=Gal-3; AltName: Full=35 kDa lectin; AltName: Full=Carbohydrate-binding protein 35; Short=CBP 35; AltName: Full=Galactose-specific lectin 3; AltName: Full=Galactoside-binding protein; Short=GALBP; AltName: Full=IgE-binding protein; AltName: Full=L-31; AltName: Full=Laminin-binding protein; AltName: Full=Lectin L-29; AltName: Full=Mac-2 antigen; Gene name Name=LGALS3 Synonyms=MAC2 Encoded on Name=LGALS3; Synonyms=MAC2 Keywords 3D-structure; Acetylation; Complete proteome; Cytoplasm; Differentiation; Disulfide bond; IgE-binding protein; Immunity; Innate immunity; Lectin; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Spliceosome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M57710; AAA35607.1; -; mRNA EMBL M35368; AAA88086.1; -; mRNA EMBL M36682; AAA36163.1; -; mRNA EMBL M64303; -; NOT_ANNOTATED_CDS; mRNA EMBL S59012; AAB26229.1; -; mRNA EMBL AF031425; AAB86584.1; -; Genomic_DNA EMBL AF031422; AAB86584.1; JOINED; Genomic_DNA EMBL AF031423; AAB86584.1; JOINED; Genomic_DNA EMBL AF031424; AAB86584.1; JOINED; Genomic_DNA EMBL AB006780; BAA22164.1; -; mRNA EMBL AK314929; BAG37435.1; -; mRNA EMBL CR456897; CAG33178.1; -; mRNA EMBL AL139316; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471061; EAW80658.1; -; Genomic_DNA EMBL BC001120; AAH01120.1; -; mRNA EMBL BC053667; AAH53667.1; -; mRNA CCDS CCDS41956.1; -; . PIR A35820; A35820; . RefSeq NP_002297.2; NM_002306.3; . UniGene Hs.531081; -; . PDB 1A3K; X-ray; 2.10 A; A=114-250 PDB 1KJL; X-ray; 1.40 A; A=105-250 PDB 1KJR; X-ray; 1.55 A; A=105-250 PDB 2NMN; X-ray; 2.45 A; A=113-250 PDB 2NMO; X-ray; 1.35 A; A=113-250 PDB 2NN8; X-ray; 1.35 A; A=113-250 PDB 2XG3; X-ray; 1.20 A; A=114-250 PDB 3AYA; X-ray; 2.00 A; A/B=117-250 PDB 3AYC; X-ray; 1.80 A; A/B=117-250 PDB 3AYD; X-ray; 1.90 A; A=117-250 PDB 3AYE; X-ray; 2.00 A; A/B=117-250 PDB 3T1L; X-ray; 1.60 A; A=108-250 PDB 3T1M; X-ray; 1.55 A; A=108-250 PDB 3ZSJ; X-ray; 0.86 A; A=113-250 PDB 3ZSK; X-ray; 0.90 A; A=114-250 PDB 3ZSL; X-ray; 1.08 A; A=114-250 PDB 3ZSM; X-ray; 1.25 A; A=114-250 PDB 4BLI; X-ray; 1.08 A; A=114-250 PDB 4BLJ; X-ray; 1.20 A; A=114-250 PDB 4BM8; X-ray; 0.96 A; A=114-250 PDB 4JC1; X-ray; 1.50 A; A=108-250 PDB 4JCK; X-ray; 1.15 A; A=108-250 PDB 4LBJ; X-ray; 1.80 A; A=114-250 PDB 4LBK; X-ray; 1.60 A; A=114-250 PDB 4LBL; X-ray; 1.58 A; A=114-250 PDB 4LBM; X-ray; 1.55 A; A=112-250 PDB 4LBN; X-ray; 1.70 A; A=112-250 PDB 4LBO; X-ray; 1.65 A; A=113-250 PDB 4R9A; X-ray; 1.20 A; A=111-250 PDB 4R9B; X-ray; 1.20 A; A=111-250 PDB 4R9C; X-ray; 1.19 A; A=111-250 PDB 4R9D; X-ray; 1.24 A; A=111-250 PDB 4RL7; X-ray; 2.00 A; A=111-250 PDB 4XBN; X-ray; 2.21 A; A=113-250 PDB 5E88; X-ray; 1.60 A; A=114-250 PDB 5E89; X-ray; 1.50 A; A=114-250 PDB 5E8A; X-ray; 1.50 A; A=114-250 PDB 5EXO; X-ray; 1.50 A; A=112-250 PDB 5H9P; X-ray; 2.04 A; A=113-250 PDB 5H9R; X-ray; 1.58 A; A=113-250 PDBsum 1A3K; -; . PDBsum 1KJL; -; . PDBsum 1KJR; -; . PDBsum 2NMN; -; . PDBsum 2NMO; -; . PDBsum 2NN8; -; . PDBsum 2XG3; -; . PDBsum 3AYA; -; . PDBsum 3AYC; -; . PDBsum 3AYD; -; . PDBsum 3AYE; -; . PDBsum 3T1L; -; . PDBsum 3T1M; -; . PDBsum 3ZSJ; -; . PDBsum 3ZSK; -; . PDBsum 3ZSL; -; . PDBsum 3ZSM; -; . PDBsum 4BLI; -; . PDBsum 4BLJ; -; . PDBsum 4BM8; -; . PDBsum 4JC1; -; . PDBsum 4JCK; -; . PDBsum 4LBJ; -; . PDBsum 4LBK; -; . PDBsum 4LBL; -; . PDBsum 4LBM; -; . PDBsum 4LBN; -; . PDBsum 4LBO; -; . PDBsum 4R9A; -; . PDBsum 4R9B; -; . PDBsum 4R9C; -; . PDBsum 4R9D; -; . PDBsum 4RL7; -; . PDBsum 4XBN; -; . PDBsum 5E88; -; . PDBsum 5E89; -; . PDBsum 5E8A; -; . PDBsum 5EXO; -; . PDBsum 5H9P; -; . PDBsum 5H9R; -; . ProteinModelPortal P17931; -; . SMR P17931; -; . BioGrid 110149; 173; . DIP DIP-45623N; -; . IntAct P17931; 57; . STRING 9606.ENSP00000254301; -; . BindingDB P17931; -; . ChEMBL CHEMBL4531; -; . iPTMnet P17931; -; . PhosphoSitePlus P17931; -; . BioMuta LGALS3; -; . DMDM 215274262; -; . DOSAC-COBS-2DPAGE P17931; -; . REPRODUCTION-2DPAGE IPI00465431; -; . UCD-2DPAGE P17931; -; . EPD P17931; -; . MaxQB P17931; -; . PaxDb P17931; -; . PeptideAtlas P17931; -; . PRIDE P17931; -; . DNASU 3958; -; . Ensembl ENST00000254301; ENSP00000254301; ENSG00000131981; . GeneID 3958; -; . KEGG hsa:3958; -; . UCSC uc001xbr.4; human; . CTD 3958; -; . DisGeNET 3958; -; . GeneCards LGALS3; -; . HGNC HGNC:6563; LGALS3; . HPA CAB005191; -; . HPA HPA003162; -; . MIM 153619; gene; . neXtProt NX_P17931; -; . OpenTargets ENSG00000131981; -; . PharmGKB PA30340; -; . eggNOG KOG3587; Eukaryota; . eggNOG ENOG4111EA0; LUCA; . GeneTree ENSGT00760000119105; -; . HOVERGEN HBG006255; -; . InParanoid P17931; -; . KO K06831; -; . OMA WGKEERH; -; . OrthoDB EOG091G0WP8; -; . PhylomeDB P17931; -; . TreeFam TF315551; -; . Reactome R-HSA-6798695; Neutrophil degranulation; . Reactome R-HSA-879415; Advanced glycosylation endproduct receptor signaling; . SIGNOR P17931; -; . ChiTaRS LGALS3; human; . EvolutionaryTrace P17931; -; . GeneWiki LGALS3; -; . GenomeRNAi 3958; -; . PMAP-CutDB Q6IBA7; -; . PRO PR:P17931; -; . Proteomes UP000005640; Chromosome 14; . Bgee ENSG00000131981; -; . CleanEx HS_LGALS3; -; . ExpressionAtlas P17931; baseline and differential; . Genevisible P17931; HS; . GO GO:0005737; C:cytoplasm; IDA:BHF-UCL; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005615; C:extracellular space; IDA:UniProtKB; . GO GO:0101003; C:ficolin-1-rich granule membrane; TAS:Reactome; . GO GO:0001772; C:immunological synapse; IDA:BHF-UCL; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB; . GO GO:0005634; C:nucleus; IDA:BHF-UCL; . GO GO:0005886; C:plasma membrane; TAS:Reactome; . GO GO:0030667; C:secretory granule membrane; TAS:Reactome; . GO GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW; . GO GO:0030246; F:carbohydrate binding; TAS:ProtInc; . GO GO:0042056; F:chemoattractant activity; IDA:BHF-UCL; . GO GO:0019863; F:IgE binding; IDA:BHF-UCL; . GO GO:0043236; F:laminin binding; IDA:BHF-UCL; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0048245; P:eosinophil chemotaxis; IDA:BHF-UCL; . GO GO:0030855; P:epithelial cell differentiation; IEP:UniProtKB; . GO GO:0045087; P:innate immune response; IEA:UniProtKB-KW; . GO GO:0048246; P:macrophage chemotaxis; IDA:BHF-UCL; . GO GO:0002548; P:monocyte chemotaxis; IDA:BHF-UCL; . GO GO:0071674; P:mononuclear cell migration; IDA:BHF-UCL; . GO GO:0006397; P:mRNA processing; IEA:UniProtKB-KW; . GO GO:0045806; P:negative regulation of endocytosis; IDA:BHF-UCL; . GO GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IDA:BHF-UCL; . GO GO:2000521; P:negative regulation of immunological synapse formation; ISS:BHF-UCL; . GO GO:2001189; P:negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; ISS:BHF-UCL; . GO GO:0050860; P:negative regulation of T cell receptor signaling pathway; ISS:BHF-UCL; . GO GO:0030593; P:neutrophil chemotaxis; IDA:BHF-UCL; . GO GO:0043312; P:neutrophil degranulation; TAS:Reactome; . GO GO:0050918; P:positive chemotaxis; IDA:BHF-UCL; . GO GO:0090280; P:positive regulation of calcium ion import; IDA:BHF-UCL; . GO GO:0071677; P:positive regulation of mononuclear cell migration; IDA:BHF-UCL; . GO GO:1902041; P:regulation of extrinsic apoptotic signaling pathway via death domain receptors; IMP:BHF-UCL; . GO GO:0070232; P:regulation of T cell apoptotic process; IDA:BHF-UCL; . GO GO:0042129; P:regulation of T cell proliferation; IMP:BHF-UCL; . GO GO:0008380; P:RNA splicing; IEA:UniProtKB-KW; . Gene3D 2.60.120.200; -; 1; . InterPro IPR013320; ConA-like_dom; . InterPro IPR015534; Galectin_3; . InterPro IPR001079; Galectin_CRD; . PANTHER PTHR11346:SF145; PTHR11346:SF145; 1; . Pfam PF00337; Gal-bind_lectin; 1; . SMART SM00908; Gal-bind_lectin; 1; . SMART SM00276; GLECT; 1; . SUPFAM SSF49899; SSF49899; 1; . PROSITE PS51304; GALECTIN; 1; .

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